The nuclear bomb marks the birth of humanity’s ability to wipe itself out, or destroy its long-run potential. No period in human history has been more dangerous or decisive. Safeguarding humanity through this period is the challenge of our time. If we are wise, our descendants may survive for an unfathomable time and achieve levels of flourishing beyond our wildest imagination. Our focus at the Powoki Foundation is on these global challenges, such as safely navigating synthetic biology and advanced artificial intelligence. We also work to foster a society with a more long-term outlook by using our knowledge and network to influence the charity landscape, especially in the Netherlands.